Saturday, April 1

diet and Nutrition – Vitamin B6

alpilean videoVitamin B6 occurs in 3 forms–pyridoxine, pyridoxamine, and pyridoxal. B6 is absorbed in the large intestine. The muscle shops more or less 75 80 % of the vitamin while the living stores about 5 10 %.

B6 is required for transaminations, ammonia release,, side-chain cleavage reactions, dehydratases and decarboxylations. The aldehyde group of its works as a Schiff base to respond with the amino groups of amino acids. It essentially acts to shuttle nitrogen between compounds.

Functions- The 3 forms of B6 could all be converted on the coenzyme PLP which aids in transamination & protein metabolism. PLP is important for glycogen degradation; it also helps with the formation of the neurotransmitter, serotonin, the nonprotein portion of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolism of tryptophan to niacin.

Overall Reactions:

· Transaminations These reactions are required to recycle and reuse nitrogen in the body. They are the initial phase of amino acid catabolism as well as the last stage in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate

· Serine/ Threonine Deamination (Dehydratases) This reaction offers the generation of the a keto acids of serine and threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+

· Decarboxylation These reactions often appear on the neuroactive amines of seratonin, tyramine, histamine, and GABA. They also are important in porphyrin synthesis, intermediates in the synthesis of sphingomyelin, taurine and lecithin, and also for the breakdown as well as desulfuration of cysteine.

· Glycogen Phosphorylase 50 % of all B6 in the body is likely to glycogen phosphorylase though the value is unknown. The reaction is vital alpine ice hack for weight loss [reference] recycling of folate and it is as follows:

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